Description

[Italian Language with English CC/Subtitles]

In this informative session, the speaker delves into the complexities of the endocannabinoid system and its implications in the field of chronic and neuropathic pain management. The presentation begins with an overview of the wind-up phenomenon in the context of neuropathic pain, highlighting the increased neuronal excitability and the role of microglia in the central nervous system. The focus then shifts to the endocannabinoid system, discussing its receptors, CB1 and CB2, and their functions in various brain regions and in immune cells. The session emphasizes that cannabinoids are not analgesics like opioids but work on pain’s destructive lines, offering a different pain management approach. The speaker also touches on the chemistry of cannabis, including its phytochemical composition and the significance of compounds like THC and CBD. The talk further explores the metabolic pathways of endocannabinoids, their neuro modulatory role, and the implications of substances like acetaminophen in enhancing anandamide levels. The presentation concludes by addressing the potential therapeutic applications of cannabinoids in areas beyond pain management, such as appetite stimulation in cachexia and anorexia, and their interactions and contraindications in drug metabolism. The session emphasizes a nuanced understanding of cannabinoids, debunking misconceptions while acknowledging their limited but significant role in certain therapeutic contexts.

This lecture is presented in Italian and is accompanied by AI-generated English subtitles. While we strive for accuracy, the subtleties of language may lead to minor discrepancies in translation. We encourage viewers to consider this when accessing this valuable resource.