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Painful Intervertebral Disc

Dr. Aaron Calodney discusses interventions for intervertebral disc pain. He begins by introducing the anatomy and microenvironment of the vertebral disc within the lumbar discovertebral complex, highlighting the importance of proteoglycans in preventing degenerative disc disease.

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Dr. Calodney goes on to discuss growth factors that influence disc homeostasis and describes results from current animal and human studies demonstrating that mesenchymal stem cell transplantation reduces disc pain.

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