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Intrathecal Pharmacokinetics
Dr. Jason Pope discusses intrathecal drug pharmacokinetics. He begins by reviewing theories of cerebrospinal fluid (CSF) flow and the importance of understanding how bidirectional, oscillatory flow affects intrathecal pharmacokinetics with respect to bolus and continuous drug infusion.
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He touches on how pulsatile flow affects targeted drug delivery and suggests that posterior catheter placement is more effective than anterior placement. He concludes by reiterating that knowledge of intrathecal drug pharmacokinetics drives therapy success.
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