1529 Results found
Articles
Noninvasive Vagus Nerve Stimulation Reduces Withdrawal-Related Affective Distress and Improves Functional Outcomes in Alcohol Use Disorder: A Feasibility and Acceptability Pilot Study
Abstract Objectives: Alcohol use disorder (AUD) is characterized by autonomic dysregulation and overactive brain stress systems, which manifests as pronounced negative emotional states in the absence of alcohol and can lead to functional impairment....
Journal:
NeuromodulationPublished:
October 3, 2025Lateral Epidural Stimulation to Decrease Glucose Levels: A Preliminary Preclinical Study
Abstract Background: Medical therapy in patients with type 2 diabetes (T2D) often has side effects and poor tolerance. Therefore, a device-based therapy may be more desirable. Objective: We investigated whether increased dorsal root nerve...
Journal:
NeuromodulationPublished:
October 3, 2025Correlation of Electrical Impedance and Evoked Potentials With Properties of the Electrode Interface Using in Situ Block-Face Imaging of the Rat Pelvic Nerve
Abstract Background: Electrical stimulation is an emerging therapy for urologic disorders. The interface between electrode and neural tissue is a critical region of interest given it affects thresholds of neural activation. Measures of electrode...
Journal:
NeuromodulationPublished:
October 3, 2025Surgical vs Percutaneous Spinal Cord Stimulation for Persistent Spinal Pain Syndrome Type 2: A Digital Pain Mapping and Pain Coverage Quantitative Assessment Combined With Multidimensional Clinical Outcome Study
Abstract Background: Persistent spinal pain syndrome type 2 (PSPS-T2) remains a significant challenge in chronic pain management, particularly when refractory to conventional treatments. Spinal cord stimulation (SCS) is an established therapeutic option, but the...
Journal:
NeuromodulationPublished:
September 19, 2025A Real-World Evaluation of Adjunctive Peripheral Nerve Stimulation for Superior Cluneal Neuropathy After Spinal Cord Stimulation
Abstract Objectives: Even with successful spinal cord stimulation (SCS) therapy, pain of peripheral nerve origin can occur. Such areas of focal pain may be suitable for peripheral nerve stimulation (PNS). We report on the...
Journal:
NeuromodulationPublished:
September 19, 2025Ultrasound Evaluation of Tibial Vasculonervous Structures for Tibial Nerve Neuromodulation: A Cross-Sectional Study
Abstract Background: Percutaneous tibial nerve neuromodulation is an effective approach for treating genitourinary and anorectal dysfunctions. However, the variability in electrode and needle placement raises concerns about standardization and safety. This study aimed to...
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NeuromodulationPublished:
September 12, 2025The Incidence of Eosinophilia in Refractory Chronic Pain Requiring Neuromodulation
Abstract Objectives: Eosinophilia is a hallmark of a variety of disease processes, but its association with chronic pain has not been well-established. We evaluated the incidence and clinical relevance of eosinophilia in patients who...
Journal:
NeuromodulationPublished:
September 5, 2025Cortical Excitability and Heart Rate Variability in Response to Short Duration Transauricular Vagus Nerve Stimulation in Healthy Adults
Abstract Background: Vagus nerve stimulation (VNS) is approved as an adjunctive therapeutic intervention in neurologic conditions, including epilepsy and primary headache disorders. Transauricular VNS (tVNS) is increasingly used as a method for noninvasively activating...
Journal:
NeuromodulationPublished:
September 5, 2025Impact of Subthalamic Nucleus Deep Brain Stimulation on Gastrointestinal Symptoms and Gastric Emptying in Parkinson’s Disease: A Systematic Review and Meta-Analysis
Abstract Objective: This systematic review and meta-analysis evaluates the efficacy of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in improving gastric motility in patients with Parkinson’s disease (PD). Materials and methods: A systematic...
Journal:
NeuromodulationPublished:
September 5, 2025Short-Term Efficacy of Sacral Neuromodulation on Cystometric Parameters in Patients With Detrusor Overactivity
Abstract Objectives: This study aimed to describe the short-term efficacy of sacral neuromodulation (SNM) on cystometric parameters in a population of patients with overactive bladder (OAB) associated with detrusor overactivity (DO). Materials and methods:...
Journal:
NeuromodulationPublished:
August 29, 2025Electro-Mechanical Mapping of the Small Intestine and the Influence of High-Energy Pacing
Abstract Purpose: Compromised electrical and mechanical activity in the gastrointestinal tract is associated with several motility disorders. Conventional treatment fails in a significant proportion of the patient population, and pacing is a promising alternative...
Journal:
NeuromodulationPublished:
August 29, 2025Insula Deep Brain Stimulation for Neuropathic Pain: A Cross-Over, Randomized, Sham-Controlled Trial
Abstract Objective: Despite neuropathic pain affecting a significant portion of the population, many people still experience refractory conditions. Here, we evaluated the efficacy and safety of posterior-superior insula deep brain stimulation for pharmaco-resistant neuropathic...
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NeuromodulationPublished:
August 22, 2025Patients’ Values, Perspectives, and Priorities on Outcome Domains for Persistent Spinal Pain Syndrome Type 2: A Focus Group Study
Abstract Rationale: Monitoring clinical outcomes in persistent spinal pain syndrome type 2 (PSPS-T2) varies widely owing to the refractory nature and diverse treatment strategies. Furthermore, it is unclear which outcome domains are most important...
Journal:
NeuromodulationPublished:
August 22, 2025The Analgesic and Antispastic Effects of Epidural Spinal Stimulation Depending on the Frequency and Intensity After Spinal Cord Injury
Abstract Objectives: Neuropathic pain and spasticity after spinal cord injury (SCI) are intractable conditions that represent distinct outcomes of sensory and motor dysfunction. Spinal cord stimulation (SCS) has been proposed as a potential therapy...
Journal:
NeuromodulationPublished:
August 15, 2025Exploring the Influence of Dorsal Root Ganglion Stimulation on Sleep Behavior in Patients With Chronic Pain
Abstract Introduction: Chronic pain is associated with sleep disturbances, with >70% of patients reporting clinically significant insomnia. Although dorsal root ganglion stimulation (DRGS) is an established therapy for focal neuropathic pain, its impact on...
Journal:
NeuromodulationPublished:
August 8, 2025Bilateral Cerebellar Intermittent Theta Burst Stimulation Enhances Swallowing Function and Cortical Reorganization in Patients With Subacute Stroke: A Randomized Single-Blind Controlled Trial
Abstract Objectives: Intermittent theta burst stimulation (iTBS) may enhance cortical excitability and induce neuroplastic changes through specific pulse patterns. This study aimed to investigate whether bilateral cerebellar hemisphere iTBS improves swallowing function in patients...
Journal:
NeuromodulationPublished:
August 8, 2025
