New Concept Otheogenic Pain

This talk explores osteogenic pain—pain originating from bone tissue—and credits Dr. Plancarte for introducing the concept. Dr. Jimenez Andrade traces the historical view of bone as merely structural, highlighting new evidence showing that bone is richly innervated, particularly with peptidergic sensory fibers, unlike skin, which has both peptidergic and non-peptidergic fibers. Using animal models of fracture and cancer, the team demonstrates that blocking the NGF/TRK pathway leads to analgesic effects. Human studies confirm similar nerve remodeling in bone metastases. The findings support a paradigm shift: bone is a distinct pain source with unique nerve characteristics, offering new therapeutic targets.