Complex Regional Pain Syndrome CRPS

The lecture addresses Complex Regional Pain Syndrome (CRPS), a neuropathic pain disorder characterized by pain disproportionate to injury, sensory-motor changes, and autonomic dysfunction. Diagnosis relies on the Budapest Criteria, ensuring accurate identification. CRPS pathophysiology involves inflammation, immune changes, peripheral and central sensitization, and autonomic alterations, guiding treatment choices. Management starts with physical and occupational therapy to prevent atrophy, followed by pharmacologic options (anti-inflammatories, anticonvulsants, antidepressants, NMDA antagonists like ketamine, and bisphosphonates). Interventional options include sympathetic blocks, spinal cord stimulation (SCS), and dorsal root ganglion (DRG) stimulation, with DRG shown superior in trials. Early, aggressive, multimodal treatment prevents chronic disability.