1421 Results found
Articles
Electroencephalographic indices for clinical endpoints during propofol anesthesia in infants-an early phase propofol biomarker-finding study
Abstract Background: Unlike expired sevoflurane concentration, propofol lacks a biomarker for its brain effect site concentration (Ce), leading to dosing imprecision particularly in infants. Electroencephalography (EEG) monitoring can serve as a biomarker for propofol...
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AnesthesiologyPublished:
May 10, 2024Perioperative Acute Renal Injury: Revisiting Pathophysiology
Abstract Background: Acute renal dysfunction and subsequent acute renal failure after cardiac surgery are associated with high mortality and morbidity. Early therapeutic or preventive intervention is hampered by the lack of an early biomarker...
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AnesthesiologyPublished:
May 10, 2024Small G-Protein Rheb Gates Mammalian Target of Rapamycin Signaling to Regulate Morphine Tolerance in Mice: Erratum
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AnesthesiologyPublished:
May 10, 2024Does celecoxib prescription for pain management impact post-tonsillectomy hemorrhage requiring surgery? A retrospective observational cohort study
Abstract Background: Adenotonsillectomy and tonsillectomy (now referred to as tonsillectomy thereafter) are common pediatric surgeries. Postoperative complications include hemorrhage requiring surgery (2-3% of cases) and pain. While non-steroidal anti-inflammatory drugs are commonly administered for...
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AnesthesiologyPublished:
May 3, 2024Addition of liposomal bupivacaine to standard bupivacaine versus standard bupivacaine alone in the supraclavicular brachial plexus block: a randomized controlled trial
Abstract Background: The analgesic effect of adding liposomal bupivacaine to standard bupivacaine in supraclavicular brachial plexus block is not known. We hypothesized that addition of liposomal bupivacaine would reduce acute postoperative pain compared to...
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AnesthesiologyPublished:
May 3, 2024Increased Postoperative Opioid Consumption in the Presence of Co-administration of 5-HT3 Antagonists with Acetaminophen: A Hospital Registry Study
Abstract Background: Acetaminophen and 5-hydroxytryptamine-type-3 (5-HT3) receptor antagonists are administered as standard prophylaxes for postoperative pain, nausea, and vomiting. Preclinical studies however suggest that 5-HT3 antagonists may compromise acetaminophen’s analgesic effect. This hospital registry...
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AnesthesiologyPublished:
May 3, 2024Influence of clinical and genetic factors on propofol dose requirements: A genome-wide association study
Abstract Background: Propofol is a widely used intravenous hypnotic. Dosing is mostly based on weight with great interindividual variation in consumption. Suggested factors affecting propofol requirements include age, gender, ethnicity, anxiety, alcohol consumption, smoking,...
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AnesthesiologyPublished:
May 3, 2024A Lesson in Loss: A Novice Anesthesiologist’s Journey
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AnesthesiologyPublished:
April 26, 2024Discovering the Intriguing Properties of Extrasynaptic γ-Aminobutyric Acid Type A Receptors
Abstract Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors. By Caraiscos VB, Elliott EM, You-Ten KE, Cheng VY, Belelli D, Newell JG, Jackson MF,...
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AnesthesiologyPublished:
April 26, 2024Effects of positive end-expiratory pressure on pulmonary perfusion distribution and intrapulmonary shunt during one-lung ventilation in pigs A randomized crossover study
Abstract Background: During one-lung ventilation (OLV), positive end-expiratory pressure (PEEP) can improve lung aeration, but might over-distend lung units and increase intrapulmonary shunt. We hypothesized that higher PEEP shifts pulmonary perfusion from the ventilated...
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AnesthesiologyPublished:
April 26, 2024Activity of the sodium leak channel maintains the excitability of paraventricular thalamus glutamatergic neurons to resist anesthetic effects of sevoflurane in mice
Abstract Background: Stimulation of the paraventricular thalamus has been found to enhance anesthesia recovery; however, the underlying molecular mechanism by which general anesthetics modulate paraventricular thalamus is unclear. Here, we aimed to test the...
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AnesthesiologyPublished:
April 26, 2024Association between Colonoscopy Sedation Type and Polyp Detection: A Registry-based Cohort Study
Abstract Background: Colorectal cancer is a leading cause of cancer-related death. Adenomas and serrated polyps are precursors of colorectal cancer, with serrated polyps being more difficult to detect during colonoscopy. The relationship between propofol...
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AnesthesiologyPublished:
April 26, 2024Does Propofol Improve Polyp Detection during Colonoscopy? The Promise and Peril of Clinical Registry Data
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AnesthesiologyPublished:
April 26, 2024Meta-analyses of Randomized Clinical Trials in Postsurgical Pain: Verify before Trusting: Erratum
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AnesthesiologyPublished:
April 26, 2024Global and regional heterogeneity of lung aeration in neonates with different respiratory disorders: a physiological, observational study
Abstract Background.: Aeration heterogeneity affects lung stress and influences outcomes in adults with acute respiratory distress syndrome (ARDS). We hypothesize that aeration heterogeneity may differ between neonatal respiratory disorders and is associated with oxygenation,...
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AnesthesiologyPublished:
April 26, 2024Safety and Efficacy of Vocacapsaicin for Management of Postsurgical Pain: A Randomized Clinical Trial
Abstract Background: Nonopioid management of postsurgical pain remains a major unmet need. Few studies have evaluated TRPV1 agonists for analgesia after surgery. We studied intraoperative vocacapsaicin, a novel prodrug of the TRPV1 agonist capsaicin,...
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AnesthesiologyPublished:
April 26, 2024Incidence and risk factors of chronic postoperative pain in same-day surgery: A prospective cohort study
Abstract Background: The amount of same-day surgery has increased markedly worldwide in recent decades, but there remains limited evidence on chronic postsurgical pain in this setting. Methods: We assessed pain 90 days after ambulatory...
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AnesthesiologyPublished:
April 26, 2024Single-Dose Intraoperative Methadone for Pain Management in Pediatric Tonsillectomy: A Randomized Double Blind Clinical Trial
Abstract Background: More than 500,000 elective tonsillectomies are performed in US children annually. Pain after pediatric tonsillectomy is common, often severe, and undertreated. There is no consensus on the optimal management of perioperative tonsillectomy...
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AnesthesiologyPublished:
April 26, 2024
