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Cutting Edge Technology Research
Dr. Ricardo Vallejo presents a powerful reflection on the evolution of spinal cord stimulation (SCS), challenging the neuron-centric view of pain modulation. Drawing on 20+ years of research, he proposes that glial cells, not just neurons, play a crucial role in chronic pain. He explains how electrical stimulation alters glial function, gene expression, and epigenetic responses, revealing new pathways for therapy. Using computational modeling and closed-loop systems, his team shows that different frequencies and waveforms trigger different cellular responses. The talk emphasizes personalized neuromodulation grounded in biology, not marketing trends, and advocates for compassionate, mechanism-based pain care.
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This presentation reviews the REACTIV8-B trial, a five-year study on restorative neurostimulation targeting L2 medial branch nerves to restore multifidus muscle function for chronic low back pain. Conducted across 26 global centers, the trial included patients with severe, refractory pain who failed conventional therapies. Results: pain scores improved from 7.3 to 2.4, Oswestry Disability Index dropped from 39 to 16, and health-related quality of life normalized. 46% eliminated opioids, and no lead migrations occurred. Unique findings include patients explanted due to cure and long-term durability without tolerance. Real-world outcomes mirror trial results, reinforcing this as a disease-modifying therapy for functional spine stability.
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Multi-Center Prospective Cohort of Intractable Chronic Low Back Pain Treated with Restorative Neurostimulation
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Activation Principles of Platelet Rich Plasma
Dr. Singh has been attending the NYNJ Pain Congress for over a decade and presented a compelling talk on platelet-rich plasma (PRP) activation and its role in regenerative medicine. Initially skeptical, his research at Weill Cornell Medicine revealed consistent functional and pain improvements in patients—even when imaging didn’t change—prompting deeper investigation into PRP dosing, growth factor release, and activation methods (calcium chloride, thrombin, freeze/thaw). He emphasized the importance of measuring platelet counts, tailoring therapy by indication, and advancing the field through standardized reporting (PLRA). His call to action: collaborate, count, and focus on patient outcomes—not just imaging.
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New Concept Osteogenic Pain
This talk explores osteogenic pain—pain originating from bone tissue—and credits Dr. Plancarte for introducing the concept. Dr. Jimenez Andrade traces the historical view of bone as merely structural, highlighting new evidence showing that bone is richly innervated, particularly with peptidergic sensory fibers, unlike skin, which has both peptidergic and non-peptidergic fibers. Using animal models of fracture and cancer, the team demonstrates that blocking the NGF/TRK pathway leads to analgesic effects. Human studies confirm similar nerve remodeling in bone metastases. The findings support a paradigm shift: bone is a distinct pain source with unique nerve characteristics, offering new therapeutic targets.
Minimally Invasive Procedures for Central and Neuroforaminal Spinal Stenosis
Dr. Steve Aydin reflects on the evolution of minimally invasive treatments for lumbar spinal stenosis, questioning whether these procedures truly change patient outcomes or mainly improve symptoms. He compares options like MILD (percutaneous lumbar decompression) and interspinous devices (Vertiflex, Minuteman), noting that while imaging rarely shows significant post-procedure change, patients often experience relief. The talk highlights challenges in patient selection, balancing risks like facet pain after spacers, and the importance of individualized algorithms for central versus foraminal stenosis. Aiden emphasizes adaptability as techniques evolve, aiming for the least invasive intervention with meaningful symptom improvement over aggressive surgical alternatives.
Watch Now
NEWEST VIDEO
Watch Now
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Dr. Ricardo Vallejo presents a powerful reflection on the evolution of spinal cord stimulation (SCS), challenging the neuron-centric view of pain modulation. Drawing on 20+ years of research, he proposes that glial cells, not just neurons, play a crucial role in chronic pain. He explains how electrical stimulation alters glial function, gene expression, and epigenetic responses, revealing new pathways for therapy. Using computational modeling and closed-loop systems, his team shows that different frequencies and waveforms trigger different cellular responses. The talk emphasizes personalized neuromodulation grounded in biology, not marketing trends, and advocates for compassionate, mechanism-based pain care.
Cutting Edge Technology Research
Watch Now
Multi-Center Prospective Cohort of Intractable Chronic Low Back Pain Treated with Restorative Neurostimulation
This presentation reviews the REACTIV8-B trial, a five-year study on restorative neurostimulation targeting L2 medial branch nerves to restore multifidus muscle function for chronic low back pain. Conducted across 26 global centers, the trial included patients with severe, refractory pain who failed conventional therapies. Results: pain scores improved from 7.3 to 2.4, Oswestry Disability Index dropped from 39 to 16, and health-related quality of life normalized. 46% eliminated opioids, and no lead migrations occurred. Unique findings include patients explanted due to cure and long-term durability without tolerance. Real-world outcomes mirror trial results, reinforcing this as a disease-modifying therapy for functional spine stability.
Watch Now
Dr. Singh has been attending the NYNJ Pain Congress for over a decade and presented a compelling talk on platelet-rich plasma (PRP) activation and its role in regenerative medicine. Initially skeptical, his research at Weill Cornell Medicine revealed consistent functional and pain improvements in patients—even when imaging didn’t change—prompting deeper investigation into PRP dosing, growth factor release, and activation methods (calcium chloride, thrombin, freeze/thaw). He emphasized the importance of measuring platelet counts, tailoring therapy by indication, and advancing the field through standardized reporting (PLRA). His call to action: collaborate, count, and focus on patient outcomes—not just imaging.
Activation Principles of Platelet Rich Plasma
Watch Now
This talk explores osteogenic pain—pain originating from bone tissue—and credits Dr. Plancarte for introducing the concept. Dr. Jimenez Andrade traces the historical view of bone as merely structural, highlighting new evidence showing that bone is richly innervated, particularly with peptidergic sensory fibers, unlike skin, which has both peptidergic and non-peptidergic fibers. Using animal models of fracture and cancer, the team demonstrates that blocking the NGF/TRK pathway leads to analgesic effects. Human studies confirm similar nerve remodeling in bone metastases. The findings support a paradigm shift: bone is a distinct pain source with unique nerve characteristics, offering new therapeutic targets.
New Concept Osteogenic Pain
Watch Now
Dr. Steve Aydin reflects on the evolution of minimally invasive treatments for lumbar spinal stenosis, questioning whether these procedures truly change patient outcomes or mainly improve symptoms. He compares options like MILD (percutaneous lumbar decompression) and interspinous devices (Vertiflex, Minuteman), noting that while imaging rarely shows significant post-procedure change, patients often experience relief. The talk highlights challenges in patient selection, balancing risks like facet pain after spacers, and the importance of individualized algorithms for central versus foraminal stenosis. Aiden emphasizes adaptability as techniques evolve, aiming for the least invasive intervention with meaningful symptom improvement over aggressive surgical alternatives.
Minimally Invasive Procedures for Central and Neuroforaminal Spinal Stenosis
