PainCast

Tag: chronic pain

  • Analgesics of the Future

    Analgesics of the Future

    [vc_row css=”.vc_custom_1517939115140{padding-right: 20px !important;padding-left: 20px !important;background-color: #fbfbfb !important;}”][vc_column][vc_column_text]Published on July 30, 2020

    Dr. Stanley Golovac discusses the importance of innovation in analgesics. Dr. Golovac makes several suggestions, including shifting from VAS scores to measures of functionality, use of alternative analgesics, and the need for new, evidence-based guidelines for opioid prescribing. He highlights a study demonstrating that inhibition of the endogenous receptor tyrosine kinase EGFR can significantly reduce chronic neuropathic pain and suggests other potential targets for alternative therapies.

    [/vc_column_text][/vc_column][/vc_row][vc_row][vc_column][vc_column_text css=”.vc_custom_1488298613118{margin-top: -20px !important;}”]

    [/vc_column_text][/vc_column][/vc_row]

  • Intrathecal Pharmacokinetics

    Intrathecal Pharmacokinetics

    [vc_row css=”.vc_custom_1517939115140{padding-right: 20px !important;padding-left: 20px !important;background-color: #fbfbfb !important;}”][vc_column][vc_column_text]Published on July 15, 2020

    Dr. Jason Pope discusses intrathecal drug pharmacokinetics. He begins by reviewing theories of cerebrospinal fluid (CSF) flow and the importance of understanding how bidirectional, oscillatory flow affects intrathecal pharmacokinetics with respect to bolus and continuous drug infusion. He touches on how pulsatile flow affects targeted drug delivery and suggests that posterior catheter placement is more effective than anterior placement. He concludes by reiterating that knowledge of intrathecal drug pharmacokinetics drives therapy success.

    [/vc_column_text][/vc_column][/vc_row][vc_row][vc_column][vc_column_text css=”.vc_custom_1488298613118{margin-top: -20px !important;}”]

    [/vc_column_text][/vc_column][/vc_row]

  • DRG Neuromodulation: Literature Update and Best Practices

    DRG Neuromodulation: Literature Update and Best Practices

    [vc_row css=”.vc_custom_1517939115140{padding-right: 20px !important;padding-left: 20px !important;background-color: #fbfbfb !important;}”][vc_column][vc_column_text]Published on June 5, 2020

    Dr. Michael Esposito provides a literature update and an overview of best practices for dorsal root ganglion (DRG) stimulation. He begins with a review of DRG anatomy and identifies characteristics that make it an ideal target for neuromodulation. Dr. Esposito then outlines the results of several large studies that demonstrate the safety and efficacy of DRG stimulation. He concludes by presenting case reports and predicts future directions, including neuroimmune modulation.

    [/vc_column_text][/vc_column][/vc_row][vc_row][vc_column][vc_column_text css=”.vc_custom_1488298613118{margin-top: -20px !important;}”]

    [/vc_column_text][/vc_column][/vc_row]

  • Tolerance and Neuroplasticity

    Tolerance and Neuroplasticity

    [vc_row css=”.vc_custom_1517939115140{padding-right: 20px !important;padding-left: 20px !important;background-color: #fbfbfb !important;}”][vc_column][vc_column_text]Published on June 3, 2020

    Dr. Peter Staats discusses the current state of spinal cord stimulation (SCS) therapy and why SCS fails in some patients. He cites a 25% long-term failure rate and identifies factors that influence successful outcomes, including patient selection, types of stimulation, and positional effects. Dr. Staats then introduces methods to improve long-term outcomes, including the use of evoked compound action potentials in a closed loop, real-time neuromonitoring system and the importance of avoiding Aβ nociceptor sensitization.

    [/vc_column_text][/vc_column][/vc_row][vc_row][vc_column][vc_column_text css=”.vc_custom_1488298613118{margin-top: -20px !important;}”]

    [/vc_column_text][/vc_column][/vc_row]

  • Differential targeting in SCS- A feasibility study

    Differential targeting in SCS- A feasibility study

    [vc_row css=”.vc_custom_1517939115140{padding-right: 20px !important;padding-left: 20px !important;background-color: #fbfbfb !important;}”][vc_column][vc_column_text]Published on May 21, 2020

    Dr. Ramsin Benyamin discusses differential target multiplexed spinal cord stimulation (DTM-SCS) for chronic back pain. He starts with a comparison of neuronal and glial cell prevalence in the spinal cord before turning to the theory of targeted, multiplexed SCS and the value of glial targeting. Dr. Benyamin provides data from a prospective study demonstrating that DTM-SCS is significantly more effective in treating back and leg pain compared to standard SCS.

    [/vc_column_text][/vc_column][/vc_row][vc_row][vc_column][vc_column_text css=”.vc_custom_1488298613118{margin-top: -20px !important;}”]

    [/vc_column_text][/vc_column][/vc_row]

  • Epidural Lysis of Adhesions Lecture

    Epidural Lysis of Adhesions Lecture

    [vc_row css=”.vc_custom_1517939115140{padding-right: 20px !important;padding-left: 20px !important;background-color: #fbfbfb !important;}”][vc_column][vc_column_text]Published on May 20, 2020

    Dr. Richard Epter discusses epidural lysis of adhesions. He begins with a brief history of epidural analgesia techniques and a review of pain generators. Dr. Epter then considers factors that influence epidural fibrosis-related pain perception and the significance of pro-inflammatory mediators in lumbar pain. He concludes with an in-depth discussion of strategies for epidural access, procedural and technical recommendations, and potential complications.

    [/vc_column_text][/vc_column][/vc_row][vc_row][vc_column][vc_column_text css=”.vc_custom_1488298613118{margin-top: -20px !important;}”]

    [/vc_column_text][/vc_column][/vc_row]

  • IASP Webinar – Why, What and How of Nutrition for People Experiencing Chronic Pain

    IASP Webinar – Why, What and How of Nutrition for People Experiencing Chronic Pain

    [vc_row css=”.vc_custom_1517939115140{padding-right: 20px !important;padding-left: 20px !important;background-color: #fbfbfb !important;}”][vc_column][vc_column_text]Published on April 10, 2020

    IASP’s 2020 Global Year for the Prevention of Pain Webinar series. Dr. Clare Collins is a Professor of Nutrition and Dietetics in the School of Health Sciences, Faculty of Health and Medicine at the University of Newcastle, NSW, Australia.

    [/vc_column_text][/vc_column][/vc_row][vc_row][vc_column][vc_column_text css=”.vc_custom_1488298613118{margin-top: -20px !important;}”]

    [/vc_column_text][/vc_column][/vc_row]