1464 Results found
Articles
10-kHz High-Frequency Spinal Cord Stimulation Significantly Reduces Proinflammatory Cytokines and Distinct Populations of T Lymphocytes in Patients With Persistent Spinal Pain Syndrome Type 2
Abstract Objectives: Persistent spinal pain syndrome type 2 (PSPS-T2) is a chronic mixed nociceptive and neuropathic pain condition that results after lumbar spinal surgery. PSPS-T2 is a highly treatment-resistant condition with less than half...
Journal:
NeuromodulationPublished:
April 18, 2025Kilohertz High-Frequency Electrical Stimulation Effectively Mitigates Hyperalgesia in Mice With Neuropathic Pain Through Regulation of the Calcium/Calmodulin-Dependent Protein Kinase II/N-Methyl-D-Aspartate 2B Signaling Pathway
Abstract Objectives: Kilohertz high-frequency electrical stimulation (KHES), an avant-garde neuromodulation strategy, is progressively emerging in the field of neuropathic pain management, showing its unique therapeutic potential. This study delves into the mechanisms by which...
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NeuromodulationPublished:
April 18, 2025Electrical Nerve Stimulation Induces Synaptic Plasticity in the Brain and the Spinal Cord: A Systematic Review
Abstract Objectives: This review aimed to compile the literature on synaptic plasticity induced by electrical nerve stimulation (ENS) in nociceptive and somatosensory circuits within the central nervous system, with a particular focus on its...
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NeuromodulationPublished:
April 11, 2025Meta-analysis of Randomized Controlled Trials on the Efficacy of Sacral Neuromodulation in Chronic Constipation
Abstract Objectives: The present systematic review aimed to assess the outcome of sacral neuromodulation (SNM) in adult patients with chronic constipation. Materials and methods: A systematic review of randomized controlled trials (RCTs) that assessed...
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NeuromodulationPublished:
April 11, 2025Management and Cost of Spinal Cord Stimulator Explants due to Infection
Abstract Objectives: Explants due to infected spinal cord stimulation (SCS) devices are a significant concern, leading to complex care needs and high costs. This study aimed to evaluate the cost of explant and subsequent...
Journal:
NeuromodulationPublished:
April 11, 2025Auricular Allodynia is Associated With Worse Outcomes in Children With Functional Abdominal Pain Disorders Using Neurostimulation
Abstract Background and aims: Percutaneous electrical nerve field stimulation (PENFS) is a minimally invasive, nonpharmacologic approach to treat children with functional abdominal pain disorders (FAPD). Allodynia refers to pain from a stimulus that does...
Journal:
NeuromodulationPublished:
April 11, 2025Transcutaneous Neuromodulation Promotes Functional Regeneration of the External Urethral Sphincter Neural Circuitry in Two Models of Nerve Lesion in Female Rats
Abstract Objective: This study investigated the effect of transcutaneous electrical stimulation of the dorsal nerve of the clitoris (DNC-TENS) on the functional recovery of the neural circuitry of the external urethral sphincter (EUS) neural...
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NeuromodulationPublished:
April 4, 2025Feasibility and Long-term Outcomes of Minimally Invasive Tubular Spinal Cord Stimulation Lead Placement
Abstract Objectives: This study primarily addressed the feasibility of implanting a spinal cord stimulation (SCS) electrode in a minimally invasive tubular approach and the required frequency of escalating to a second tube or an...
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NeuromodulationPublished:
April 4, 2025Health Economic Evaluation and Patient Perspectives on a Virtual Clinic: Advancing Digital Remote Care in Health Care
Abstract Introduction: The increasing adoption of digital health care solutions offers a transformative opportunity to improve patient access while addressing sustainability and cost-efficiency challenges. Our study evaluates a virtual remote care system (VRCS) that...
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NeuromodulationPublished:
April 4, 2025Adverse Events Associated With Peripheral Nerve Stimulation: An Analysis of the MAUDE Data base and Implications for Pain and Spine Clinicians
Abstract Of background data: The use of peripheral nerve stimulation (PNS) devices within pain and spine-related care has increased significantly in recent years. The United States Food and Drug Administration (FDA)-approved indications for PNS...
Journal:
NeuromodulationPublished:
April 4, 2025Computational Optimization of Spinal Cord Stimulation for Dorsal Horn Interneuron Polarization
Abstract Objectives: The proposed mechanisms of spinal cord stimulation (SCS) follow the polarization of dorsal column axons; however, the development of subparesthesia SCS has encouraged the consideration of different targets. Given their relative proximity...
Journal:
NeuromodulationPublished:
April 4, 2025Effects of Ultrasound-Guided Percutaneous Neuromodulation on Shoulder Muscle Strength in CrossFit Athletes: A Pilot Randomized Controlled Trial
Abstract Background: CrossFit integrates diverse functional movements to optimize overall fitness, with muscle strength training being a core component. Ultrasound-guided percutaneous neuromodulation (US-guided PNM) has emerged as a potential adjunct to enhance muscle strength...
Journal:
NeuromodulationPublished:
April 4, 2025Accelerated Transcutaneous Auricular Vagus Nerve Stimulation for Inpatient Depression and Anxiety: The iWAVE Open Label Pilot Trial
Abstract Introduction: Brain stimulation is not a common inpatient psychiatric treatment; however, there are an increasing number of neuromodulation treatments approved for psychiatric indications. Noninvasive techniques, such as transcutaneous auricular vagus nerve stimulation (taVNS),...
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NeuromodulationPublished:
March 28, 2025Fluoroscopy-Guided Percutaneous Placement of Peripheral Nerve Stimulator of the Cervical Medial Branches in Patients With Treatment-Refractory Occipital Neuralgia: A Case Series
Abstract Background: Pain from occipital neuralgia (ON) stems from the compression of the greater occipital nerve, muscle hypertrophy, or spasm. C2-C3 facet joint pain also is implicated in ON, given the third occipital nerve’s...
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NeuromodulationPublished:
March 28, 2025Repetitive Transcranial Magnetic Stimulation for Refractory and Super-refractory Status Epilepticus: A Systematic Review
Abstract Rationale: Off-label treatments are often considered to treat refractory status epilepticus (RSE) and superrefractory status epilepticus (SRSE). To investigate the efficacy of repetitive transcranial magnetic stimulation (rTMS) as a treatment for (S)RSE, we...
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NeuromodulationPublished:
March 28, 2025Mapping Healthy and Epileptic States in the Centromedian Nucleus Region
Abstract Background: Neuromodulation of the centromedian nucleus (CM) has shown beneficial effects on seizure frequency. The effects of stimulation vary by location within the CM region, and during closed-loop stimulation, different contacts have been...
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NeuromodulationPublished:
March 28, 2025Assessing the Efficacy of Spinal Cord Stimulation in Managing Painful Diabetic Neuropathy: A Systematic Review and Meta-Analysis
Abstract Background: Diabetes mellitus affects more than half a billion people globally, often leading to painful diabetic neuropathy (PDN). Spinal cord stimulation (SCS) has emerged as a promising treatment for PDN. Objective: This meta-analysis...
Journal:
NeuromodulationPublished:
March 14, 2025Noninvasive Vagus Nerve Stimulation in Parkinson’s Disease: A Systematic Review
Abstract Background: While pharmacologic interventions remain the mainstay of Parkinson’s disease (PD) treatment, alternative approaches such as vagus nerve stimulation (VNS) have drawn attention for their potential in managing PD symptoms. Objective: We aimed...
Journal:
NeuromodulationPublished:
March 14, 2025
