Molecular Biology of Pain

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Molecular Biology of Pain

Published on November 24, 2020

Dr. Nebojsa Nick Knezevic discusses innovative strategies to target the molecular mechanisms of pain. After reviewing nociceptive and neuropathic pain, inflammatory cytokines, and nociceptor diversity, he introduces pain-related voltage gated ion channels, glial and inflammatory cells, and G-protein-coupled receptor kinase 2 (GRK2). Dr. Knezevic provides compelling evidence that these are promising targets for pain treatment using strategies including monoclonal antibodies, biased μ-opioid receptor ligands, stem cells, and targeted gene therapy.