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The Basis of Neuropathic Pain
Where does neuropathic pain come from? This type of pain is a complex phenomenon that remains little understood. Here, renowned pain researcher Marshall Devor, PhD, describes the biological mechanisms of neuropathic pain and explains why some pain therapies succeed or fail. Prof. Devor also discusses why studying unconsciousness helps us better understand pain.
This experience is powered by CMEfy – an AI-powered platform that directs learners along a pathway to capture reflections at point of inspiration, point of care. Clinicians may earn CME/CE credit via ReflectCE, the accredited activity portal. Learn more at about.cmefy.com/cme-info
CONGRATULATIONS TO DR. DEVOR WHOM I HAVENT HEARD A LECTURE BEFORE BUT HAD THE PRIVILEGE TO HAVE HEARD HIS MENTOR PATRIC WALL IN LA IN 1995!!
I WOULD LIKE TO TO POINT OUT THAT THE DEFINITION OF PAIN (REVIZED) BY IASP HAS PAIN AS A SENSATION OF HUMANS WHEN THEY ARE CONCIOUS AND ARE ABLE TO REPORT IT AS SUCH. THUS GENERAL ANESTHETICS DO NOT SEEM TO BLOCK PAIN IN THAT RESPECT BUT RATHER TO SHUT DOWN THE CNS AND TERMINATE OUR ABILITY TO REPORT PAIN. FURTHERMORE WHEN AT CERTAIN DEPTHS OF GENERAL ANESTHESIA (PRODUCED BY USING ONLY GENERAL ANESTHETICS AND NOT OPIATES OR OTHER ANALGESICS) SURGERY MAY STILL EVOKE POWERFUL AUTONOMIC RESPONSES SUCH AS TACHYCARDIA, RAISED BLOOD PRESSURE AND SWEATING INDICATIVE OF A FIGHT OR FLIGHT STRESS RESPONSE WE OBSERVE IN CONCIOUS INDIVIDUALS IN PAIN.
MAY IT BE MORE PLAUSIBLE THAT ANATOMIC LOCI WITHIN THE CNS THAT ARE KEY TO CONCIOUSNES AND THE SITE OF ACTION OF GENERAL ANESTHETICS CONVERGE OR INTERACT WITH CORRESPONDING ONES RESPONSIBLE FOR BLOCKING NOXIOUS STIMULI OR PAIN IN GENERAL???
OVERSIMPLIFIED THE ABOVE EXPLAINS WHY WHEN WE ARE ASLEEP WE MAY WAKE DUE TO NOXIOUS STIMULATION AND WHEN IN PAIN WE CANNOT GO TO SLEEP!!