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Preventive use of Melatonin in the Covid 19 Pandemic

JuanCarlos Flores on March 30, 2020 at 11:46 am
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    • JuanCarlos FloresJuanCarlos Flores
      Joined: Nov 7, 2016
      Posts: 2

      See the full April 2, 2020 updated report here:

      Fast Track Report
      “Melatonin, analgesic hormone that relieves inflammation, among many other effects”(1, 2)

      The author wishes to state that this is not his field of expertise and is not a consultant on the subject; his work is has been conducted in an attempt to help, like many other colleagues in the context of the pandemic and is based on a thorough review of experimental and clinical literature and on consultation with top level experts, for which reason he considers that the protocol is reliable. Queries must be submitted to the relevant authorities. The author merely recommends that, since there is no clinical experience, it is necessary to conduct a prospective study measuring the recommended variables that were identified in different disease scenarios and in this way confirm if humankind has found what is being sought.

      Melatonin and its effects on lung lesions, inflammatory storm and COVID-19 related mortality.

      Lung involvement is considered to be the first cause of death in the current coronavirus pandemic. The severity of the inflammatory storm triggered by the viral infection has been identified as the main factor in fulminant lung conditions. Intervening in an early phase might help to prevent or attenuate the consequences of this entity and would help reduce the number of deaths. Further, it would prevent the most severe scenario by attenuating the high impact created by the demand for resources that are difficult to plan when it is impossible to stop the admission of patients to critical areas where health-care professionals are the most exposed. This demand has reached such magnitude and scarcity of resources is so dramatic that in the first economy in the world the FDA has authorized simultaneous mechanical ventilation of up to 4 patients in one ventilator (1-4).
      Elderly patients show significantly higher mortality and cardiovascular diseases create high risk of refractory response and secondary infections. The severity of lung lesion has been confirmed in retrospective mortality studies conducted in Wuhan. Out of a total of 68 fatal cases, 36 patients (53%) died of respiratory insufficiency, 5 patients (7%) of myocardial damage and circulatory failure, 22 (33%) of both causes and 5 of unknown cause.
      Another study of 155 consecutive confirmed patients of COVID-19 in Zhongnan Hospital, Wuhan non-remission of clinical and radiological findings was observed within the first 10 days of hospitalization in 50% of the COVID-19 +patients…

      See the full April 2, 2020 updated report here:“high-dose”-to-p-revent-inflammatory-storm-COVID19_ENG.pdf

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