High-concentration topical capsaicin is used as a second-line treatment for neuropathic pain. Transient, mild burning sensation and erythema are expected adverse drug reactions. Here, we report the first case of second degree burn after the application of a high-concentration topical capsaicin patch with secondary mobility sequelae. Nine months after the application, neuropathic pain still remained and the patient described mobility difficulties in daily activities, preventing her from returning to work. This report aims to raise the question of the benefit/risk ratio of high concentration topical capsaicin.
Keywords: adverse drug reaction; capsaicin; neuropathic pain; pharmacovigilance; sequelae.
© 2022 The Authors. Pain Practice published by Wiley Periodicals LLC on behalf of World Institute of Pain.